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KMID : 0043319970200030239
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Archives of Pharmacal Research
1997 Volume.20 No. 3 p.239 ~ p.246
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Changes of Nitric Oxide Synthase Activity and Free Methylarginines Contents in Regenerating Rat Liver after Partial Hepatectomy
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Lee Young-Jin
Nam Suk-Woo
Seo Dong-Wan
Ahn Seong-Hoon
Ko Young-Kwon
Sung Sae-Seok
Han Jeung-Whan
Hong Sung-Youl
Lee Hyang-Woo
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Abstract
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In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/ nitrate content had no timed response, revealing no significant difference between shamoperated and partially hepatectomized rat liver. Contents of free methylarginines in liver tissue were increased biphasically in a time-dependent manner after PH. However, those in serum did not exhibit the same patterns as in liver. Taken together, the results suggest that -monomethyl-L-arginine (MMA) and -dimethylarginine (DMA) play a role in inhibiting nitric oxide (NO) synthesis in regenerating rat liver because the increase of their contents was synchronized with NOS expression.
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KEYWORD
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N - Monomethyl-L-arginine, N, N, -Dimethylarginine, Mitric oxide, Partial hepatectomy
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